Thromboelastogram-Guided Transfusion Therapy Reduces Blood-Component Transfusion and Improves Coagulation Function during Orthopedic Surgery

Massive bleeding is a serious medical complication arising from trauma, surgery, and invasive procedures. In this case, timely effective hemostasis must be applied to patients. The aim of study compare transfusion therapies guided by thromboelastogram (TEG) conventional coagulation tests (CCTs) during orthopedic focusing on blood-component function patients who underwent surgery in our hospital May 2019 November 2020 were retrospectively analyzed. According different transfusion-guiding strategies, the assigned into CCT group containing 214 TEG 266 used fewer volumes blood products including red cell (RBC) suspension, fresh-frozen plasma, cryoprecipitate, apheresis platelets than ( P < 0.05 ). After hemoglobin (Hb) RBC counts decreased, but white (WBC) increased all receiving whether therapy or CCTs. Importantly, exhibited WBC concomitant with higher Hb more id="M2"> There was no significant difference platelet (PLT) between two groups before after id="M3"> > Significant declines thrombin time (TT), partial activated thromboplastin (PATT), prothrombin (PT), d-dimer (D-D), along an increase fibrinogen (FIB) observed surgery. showed reduced TT, PATT, PT, D-D, elevated FIB compared id="M4"> Posttransfusion, id="M5"> K value (time reach certain clot strength) id="M6"> R (coagulation reaction time) angle (α) (clot formation rate), MA (maximum amplitude), CI index) id="M7"> When liver assessed, it found that levels alanine aminotransferase (ALT), aspartate (AST), total serum bilirubin (TBIL) significantly, albumin (ALB) decreased lower ALT, AST, TBIL level ALB id="M8"> With regard renal function, had creatinine (Scr) urea nitrogen (BUN) declined uric acid (UA) surgery; however, Scr BUN UA id="M9"> view above data, TEG-guided could reduce use products, optimize components, improve for undergoing may prevent dysfunction